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2005/12/7(¼ö)
HIV Ç×ü P18¿¡ ´ëÇÑ ¹®Á¦Á¦±â  

[¼³¸í : ÀÌÅ»¸®¾ÆÀÇ ¹Ð¶ó³ë ´ëÇÐ ¿¤ »çÄÚ º´¿øÀÇ Àǻ簡 Á¦±âÇÑ P18¿¡ ´ëÇÑ Àǹ®ÀÔ´Ï´Ù. ¿¡ÀÌÁî °úÇÐÀÚµéÀº P18ÀÌ HIV Ç×ü¶ó°í ÁÖÀåÇÕ´Ï´Ù. ±×·±µ¥ ¾Æ·¡ Àǹ®Àº HIV À½¼ºÀο¡°Ô¼­ P18ÀÌ »óÈ£¹ÝÀÀÀ» º¸¿´´Ù°í »ó¼úÇÕ´Ï´Ù. Áï, P18Àº HIV Ç×ü°¡ ¾Æ´Ñ, ´©±¸¿¡°Ô³ª ÈçÈ÷ ÀÖ´Â Ç×üÀÎ °ÍÀÔ´Ï´Ù.]

¿ø¹® : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2456086&itool=iconabstr&query_hl=8

Monoclonal antibodies to the human immunodeficiency virus p18 protein cross-react with normal human tissues.  

Parravicini CL  , Klatzmann D  , Jaffray P  , Costanzi G  , Gluckman JC  .

5th Chair of Pathological Anatomy and Histology, University of Milano, Hospital L. Sacco, Italy.


The immunohistochemical reactivity of four monoclonal antibodies (MAbs): CVK, 49-5, 49-6 and 63-FH2, raised against the p18 protein of HIV-1 was assessed in tissues obtained from HIV-infected and uninfected individuals. As already reported, all the MAbs specifically labelled follicular dendritic cells (FDC) in lymph nodes from HIV-infected patients with lymphadenopathy, and cells of microglial nodules in the brain from patients with AIDS-related encephalopathy. However, cross-reactivity with normal uninfected tissues was also observed: epithelial cells of the skin, the thymus and tonsils with CVK, and astrocytes in the brain of 49-6 and 63-FH2. Such cross-reactivities suggest that 'molecular mimicry' could exist between p18 of HIV and normal constituents of human cells. This phenomenon could be relevant for the diagnostic use of anti-p18 MAbs on pathological specimens, and it could be of importance in the pathophysiology of HIV infection.


PMID: 2456086 [PubMed - indexed for MEDLINE]

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