2005/12/7(수)

HIV 항체 P18에 대한 문제제기   [설명 : 이탈리아의 밀라노 대학 엘 사코 병원의 의사가 제기한 P18에 대한 의문입니다. 에이즈 과학자들은 P18이 HIV 항체라고 주장합니다. 그런데 아래 의문은 HIV 음성인에게서 P18이 상호반응을 보였다고 상술합니다. 즉, P18은 HIV 항체가 아닌, 누구에게나 흔히 있는 항체인 것입니다.] 원문 : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2456086&itool=iconabstr&query_hl=8 Monoclonal antibodies to the human immunodeficiency virus p18 protein cross-react with normal human tissues.   Parravicini CL  , Klatzmann D  , Jaffray P  , Costanzi G  , Gluckman JC  . 5th Chair of Pathological Anatomy and Histology, University of Milano, Hospital L. Sacco, Italy. The immunohistochemical reactivity of four monoclonal antibodies (MAbs): CVK, 49-5, 49-6 and 63-FH2, raised against the p18 protein of HIV-1 was assessed in tissues obtained from HIV-infected and uninfected individuals. As already reported, all the MAbs specifically labelled follicular dendritic cells (FDC) in lymph nodes from HIV-infected patients with lymphadenopathy, and cells of microglial nodules in the brain from patients with AIDS-related encephalopathy. However, cross-reactivity with normal uninfected tissues was also observed: epithelial cells of the skin, the thymus and tonsils with CVK, and astrocytes in the brain of 49-6 and 63-FH2. Such cross-reactivities suggest that 'molecular mimicry' could exist between p18 of HIV and normal constituents of human cells. This phenomenon could be relevant for the diagnostic use of anti-p18 MAbs on pathological specimens, and it could be of importance in the pathophysiology of HIV infection. PMID: 2456086 [PubMed - indexed for MEDLINE]