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자. 이것은 디시의학도가 내세운 논리입니다   Goth's Medical pharmacology에서 chapter 60. antiviral agent의 AZT에 관한 부분이다. 횽이 좀있다 나가야 되서 너한테 숙제 하나 내주께 ㄲㄲㄲㄲ 니가 이거 읽어보고 뜻이 이해되면 그때부턴 횽이 상대해 줄테니까 열심히 해봐 캐돌대가리 색히야. The advent of AIDS causedby human immunodeficiency virus(HIV) has spurred development of a wide variety of antiviral components. Trial with 3'-azido-3'deoxythymidine showed efficacy for AIDS victims with Pneumocytis carini pneumonia(PCP) or for HIV-positive patients with an absolute helper/inducer(CD4+,T4+) T-cell count of less than 200/mm (adult or children) Although commonly referred to in the United States as AZT, the compound has been renamed zidovudine(Retrovir). It is available as 100mg capsules, a syrup with 50mg/5ml, and for IV infusion(10mg/ml) The drug interrupts elongation of DNA chains, making it impossible for the virus to complete DNA synthesys and reproduce. In doses of at least 200mg every 4 hours, patients with low CD4+ lymphocyte counts dah fewer infectious complecations than untreated controls, had a trasient rise in circulationg T4-lymphocytes, and could manifest delayed hypersensitivity. Recently, dasage of 100mg 5 times daily significantly reduced the time to onset of PCP in those asynptomatic HIV-positive patients with CD4+ lymphocyte counts <500/mm. serious side effects, such as sever anemia necessitating transfusions, headache, myalgias, and gastrointestinal intolerance, have been observed. The drug may also crcinogenic. Many other agents, including dideoxyinosone(ddI, didanosone, Vidox), dideoxycytidine(ddC), and soluble CD4+, are under investigation. 낄낄. 넘 쉽나. 그리고 antiviral agent 엔 Aciclovir랑 Interferon계열의 약물이 있는데 각각의 Pharmacokinetics에 대해 설명해 볼까? 횽도 약대는 아니라 아주 자세힌 모르지만 약리학과 미생물학에 서술된 정도는 안단다. 다음은 HIV의 pathogenesis다. Microbiology에서 캐간단하고 쉽게 설명된 부분이니까 너같은 캐찌질이한텐 제격일것 같구나. 이정도 영어도 안되면 접싯물은 내가 줄테니 너는 코를 박거라 풉 The main determinant in both pathogenesis and the disease caused by HIV is the tropism of this virus for CD4-expressiing cells, namely the helper and delayed-type hypersensitivity T cells, together with macrophages and some brain cells. The interactions between HIV and the immune system are now known to be cignificnatly more dynamic than scientists first thought. It was originally belived that after infecting CD4 cells the virus replicated and then established latency. Activation of the infected CD4 Tcell at a later date, for example by contact with a foreign antigen, was then belived to result in viral killing of the cel. Recent evidence indicated that HIV replicates prodigiously and destroys many cells of the immune system everyday. However, this growth is countered, usually for many years, by a vigorous host-defence response that prevents the virus from multiplying out of control. Desruction of CD4+ cell is achieved in several ways, including cytotoxic T-cell Lysis, NK cells, and antibody dependent cellular cytotoxicity. Ultimately, however, the balance of power shifts so that HIV gains the upper hand, resulting in the severe immunodeficiency characteristic of full blwn AIDS. The CD4 T cells are central to the initiation of an immune response. They relapse lymphokines required for the activation of macrophages, other T cells, B cells, and NK cells. When the number of  these cells is reduced substatiallly by HIV infection, antigen-specific immune response, especially cellular response, are in capacitated and humoral response uncontrolled. The abilities of HIV to disable the immune system and alter its antigenicity by repreated mutation allow the virus to escape compete immune clearance and prevent disease rsolution. HIV infection also has effects onthe nervous system. It is present in the brain, mainly in macrophages but also in macroglial, oligodedroglial, and capillary endothelial cells. Most AIDS patients develop neurological disease ajd it has been suggested that macrophages carry the virus into brain. 이제 알겠니? 이거조차 이해가 안되면 아까 횽이 말했듯 접싯물에 코박고 디지등가 디지기 싫으면 일단Cell biology(천페이지쯤 된다) 공부하고 그다음 Biochemistry을 공부하고(역시 신문활자로 천페이지쯤 된다) 그다음 Histology 공부하고 (요건 좀 적다. 할만할끄다) 그다음 Immunology 공부하고 나면(머리에 쥐좀 날거다.너같은 빙신은 벤자민 쇼트코스나 봐.) 저는 영어를 모릅니다 하지만 디시의학도들이 얼마나 잘못된길을 가고 잇는지 .. 나는 알리고 샆습니다 회원님들의 자문을 구합니다.